Discovery and Neurotoxicity

 

 
High-content imaging.png

High-content Imaging

Neurons carrying a GFP-reporter can be used for high-content imaging with automated analysis of neuron morphology such as neurite number, length, and branching complexity.

 

Pharmacology

Motor neurons with a luciferase reporter show a typical S-curve pharmacological response.

pharmacology.png
 
Functional Activity.png

Functional Activity - Calcium Influx

Calcium influx of mature neurons (Day 10) can be measured following electric field stimulation.

 

Functional Activity – Axon Potentials

Axon potential magnitude and frequency can be measured using traditional electrophysiology techniques.

axon potentials.png
 
Multi-electrode.png

Functional Activity – Multi-Electrode Array (MEA)

Spike activity over the entire culture can be monitored using multi-electrode array.